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KMID : 0363219700080020023
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Korean Journal of Dermatology
1970 Volume.8 No. 2 p.23 ~ p.29
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Effect of Some Immunosuppressive Agents on the Survival of Experimental Skin Homografts in Rats.
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Abstract
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Anti-rat lymphocyte rabbit serum was prepared with lymphoid tissue of rat sples Prednisolone, Imuran and this antiserum were used to prolong the survival of f thickness skin homografts in albino rats.
The results were as follows.
1. Administration of the anti-rat lymphocyte rabbit serum in a dose of 0.3cc far I days before grafting and 0. 3cc every 3 days until rejection resulted in prolong of the survival of the grafts. (Mean, 15.3 days)
2. Administration of prednisolone to the recipients in a dose of 2mg/kg/day fry 7 days before grafting to the time of rejection resulted in prolongation of surving of the grafts. (Mean, 8.4 days)
3. Administration of Imuran to the recipients in a dose of 5mg/kg/day from 7 before grafting to the time of rejection resulted in prolongation of the surving of the grafts. (Mean, 14.6 days)
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